PRP In Pattern Hair Loss

Author
Dr. Chiara Insalaco, Plastic and Reconstructive Surgeon, PhD, Tor Vergata University of Rome, Italy

Title
Abstract: PRP In Pattern Hair Loss: Comparison Of Two Methods Of PRP Activation, Calcium Gluconate vs Sonication

 

Hair loss affects millions worldwide. The most common form of alopecia, androgenetic alopecia, affects 30% of males before the age of 30, and 50 % by the age of 50. By age 70, approximately 80 % of Caucasian men and 60% of Caucasian women are affected by some degree of hair loss.
PRP is an autologous, plasma derived, concentrate able to stimulate the survival and growth of follicles.
The mechanisms of action of PRP is due to the interaction of platelet growth factors with follicular stem cells , to its anti-inflammatory action and to its immunomodulatory activity in the regulation of expression and chemotaxis of pro-inflammatory cytokines.

Objectives
There are many techniques to activate PRP.
In this study we compared two different methods to activate PRP: Calcium Gluconate versus Sonication.
Platelet sonication is a new method performed by submerging platelet-containing plastic bags in an ultrasonic bath, with a frequency > 20 kHz.

Patients and Method
We involved a study population of 40 patients, with androgenic alopecia that are a Norwood 2-6 or a Ludwing II or III.
We obtained the PRP with the use of the Arthrex Angel® device.
The scalp was divided into two parts. Right and left sides of the scalp are anatomical mirror images. In this way we minimize any effect due to recipient area influence. On one part of the scalp we injected PRP activated by Calcium Gluconate; on the other part of the scalp we would inject a PRP activated by Sonication.
We injected the affected area of hair loss at monthly intervals for three months.
All patients were evaluated at 4 months, 6 months and 12 months, with the help of global photography, physician and patient global assessment scale, and standardized Phototrichograms.
Our aim is to evaluate the best activation method of PRP in increasing of hair density and hair diameter.

Full presentation available during the Ankara May 2017 FUE Europe convention

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